Professor X had ONE weakness is a YTMND created by Super-Penguin on August 7, 2005.
The image provided in the YTMND is actually from the comic Ultimate X-men Issue # 49. The character pushing Professor X is Mister Sinister.
The humor of the statement is that Professor X is all but invincible, but the fact that he is confined to a wheelchair makes him vulnerable to accidents involving staircases.
This specific YTMND has spawned several "...One Weakness" fads which visualize the most common Achilles Heel of household names, places, and people.
Most commonly bashed is the Windows operating system for PCs as well as several video game and pop-culture icons.
The sound file accompanying this is a digital remix of the Axel F tune, first seen online in ABS's RGB.
KHAN! · Barrel Roll · Picard Song · Stapler · Conan is... · Future Conan · NSMB · Nooo! · Sonic says · What is Love · Burger King · Ualuealuealeuale · Brian Peppers · ...has one weakness. · O RLY? · OMG, secret Nazi... · I love bell peppers · CATCH THAT MAN! · Facial Expressions · lol, internet · Safety Not Guaranteed · PTKFGS · Nintendo 64 kid · Bill Cosby · Epic Maneuver · NEDM · Cake Song
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Music-related fads · Video game-related fads · Miscellaneous fads · In-jokes